Sensoril® Joint Health Study Published


A New Human Clinical Study Published in The Journal of Ayurveda And Integrative Medicine, Shows Natreon’s Sensoril® (Standardized Aqueous Extract of Withania somnifera) Can Significantly Improve Joint Health. 

Welcome news for those seeking a naturally derived, non-GMO, organic vegetarian alternative to glucosamine and chondroitin combination

Millions of Americans identify themselves as vegetarians or say they follow a largely vegetarian diet. Yet the most common natural approach to managing joint discomfort is a combination of animal-derived glucosamine and chondroitin. Now results of a human clinical trial published in the Journal of Ayurveda and Integrative Medicine provides strong evidence that Natreon’s Sensoril®, a multi-patented, standardized aqueous botanical extract of Ashwagandha (Withania somnifera) roots and leaves, provides an effective vegetarian alternative for promoting joint health.

Sometimes called “Indian ginseng” because of its rejuvenating properties, Ashwagangha has been used for thousands of years in Ayurvedic medicine. It is known to possess a multitude of health benefits including helping to enhance joint and cardiovascular health, anti-stress, cognitive function and energy.

This 12-week, randomized, double-blind, placebo-controlled study evaluated two different dosages of Natreon’s Sensoril® on 60 participants with knee joint discomfort. The subjects were randomized into three groups who received either 125 mg Sensoril®, 250 mg Sensoril® or a placebo twice daily.

The study subjects were evaluated using a Modified WOMAC Index, Knee Swelling Index (KSI) and Visual Analog Scale (VAS) at baseline and after weeks 8 and 12. At the end of 12 weeks, consumption of both the 125 mg and 250 mg twice daily dosages of Sensoril® produced significant reductions in all three parameters compared to placebo, in a dose-dependent manner. Those in the 250 mg group also experienced significant improvements at the end of weeks 4 and 8, which is a faster response time than has usually been observed in previous joint health studies evaluating glucosamine and chondroitin. Sensoril® was also well tolerated in the current study, with no reports of significant GI issues while the use of rescue medication was lower in the Sensoril® groups compared to the placebo group.

The researchers were careful to point out that, “Chemical composition of W. somnifera extracts can vary widely depending on which part of the plant is used as well as the extraction solvent and procedure. Thus different extracts may elicit different clinical responses.” Sensoril® possesses the most potent levels of health-enhancing withanolide glycoside bioactive constituents (standardized to -> 10%) in the industry, due to an aqueous extraction process and a unique patented composition which is allergen-free.

“The significant joint health benefits that occurred from consumption of both the 125 mg and 250 mg twice daily doses of Sensoril® in this study is a very exciting result, and expands the breadth of condition-specific areas addressed by Sensoril® to include support of healthy joint function. These daily dosage amounts are also much lower than what is recommended for glucosamine and chondroitin, which will also help with compliance,” noted Dr. Aparna Kalidindi of Natreon, who added that this opens the doors for the inclusion of Sensoril® in sports nutrition and joint health dietary supplement products.

Previous human clinical trials have shown that Sensoril® possesses powerful adaptogenic properties which help promote a feeling of balance and calm while reducing fatigue and increasing mental focus. “Sensoril® is an experiential product. You can really feel it working. In addition, this proprietary nutraceutical has been sold in the market for 14 years without any adverse reports,” Dr. Aparana Kalidindi confirmed.

In addition to being vegetarian, Sensoril® is non-GMO, self-affirmed GRAS, organic as well as Kosher- and Halal-certified. It is currently used in hundreds of dietary supplement products. With greater than 90 percent solubility, it is also ideal for powdered drink mixes.

The full study is available at:

Media Note: For additional information or to schedule an interview, contact Media Relations, Inc. at 952-697-5220.

About Natreon, Inc.:

Natreon Inc. is a 18-year-old company located in New Jersey with a state of the art R&D facility in Kolkata, India, and is focused on developing and marketing Ayurvedic products backed by extensive research, high degree of standardization, multiple clinical studies, safety studies, and intellectual property. Natreon’s R&D team is headed by Prof. Shibnath Ghosal, a Fulbright scholar and an eminent natural product chemist with hundreds of publications in scientific journals and a group of Ph.D. and Master’s level scientists. Natreon’s scientific research includes process optimization, development of chromatographic analytical methods such as HPLC, HPTLC, GC-MS and LC-MS for standardization, development of marker compounds, and pharmacological studies. Safety studies are done in the USA and clinical studies are conducted in reputed institutes in India as well as the USA.

For more information on Sensoril® and Natreon’s other patented ingredients, please visit

Natreon, Inc. Key Employees:

Dr. Sanni Raju – CEO/Chairman

Jeff Lind – VP, Sales and Marketing

Dr. Aparna Kalidindi – Manager, Technical Sales and Marketing

Nicole Stirling – Account Executive

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